2013•ChemInformRequires access
ChemInform Abstract: α‐Lithiation—Electrophile Trapping of N‐Thiopivaloylazetidin‐3‐ol: Stereoselective Synthesis of 2‐Substituted 3‐Hydroxyazetidines.
David M. Hodgson, Christopher I. Pearson, Amber L. Thompson
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Abstract
Abstract Treatment of the azetidinol (I) with sBuLi followed by reaction with various electrophiles results in stereoselective formation of 2,3‐trans‐substituted derivatives with exception of CD3OD which predominantly yields the cis‐product.