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2019•Journal of Cutaneous and Aesthetic SurgeryOpen access

A randomized controlled study comparing the efficacy of topical 5% tranexamic acid solution versus 3% hydroquinone cream in melasma

Rajeshwari Dabas, Manasa Shettisara Janney, Radhakrishnan Subramaniyan, Sandeep Lal, Niyor Mukuta Das, Satish K Godara

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Abstract

BACKGROUND AND AIMS: Melasma is a common, relapsing, acquired, symmetrical facial hypermelanosis with no universally effective therapy. Hydroquinone (HQ) is considered the gold standard in the treatment of melasma till date. Tranexamic acid (TA) is an upcoming molecule being explored in melasma therapy and has shown optimistic results in preliminary trials. This study aimed to compare the efficacy of topical 5% TA solution with 3% HQ cream in the treatment of melasma in Indian skin. MATERIAL AND METHODS: -value of <0.05 was considered to be statistically significant. RESULTS: value = 0.03) in view of lesser adverse effects. CONCLUSIONS: Topical 5% TA solution is as effective as 3% HQ cream in melasma with enhanced patient satisfaction.

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What this paper is about

BACKGROUND AND AIMS: Melasma is a common, relapsing, acquired, symmetrical facial hypermelanosis with no universally effective therapy. Hydroquinone (HQ) is considered the gold standard in the treatment of melasma till date. Tranexamic acid (TA) is an upcoming molecule being explored in melasma therapy and has shown optimistic results in preliminary trials. This study aimed to compare the efficacy of topical 5% TA solution with 3% HQ cream in the treatment of melasma in Indian skin. MATERIAL AND METHODS: -value of <0.05 was considered to be statistically significant. RESULTS: value = 0.03) in view of lesser adverse effects. CONCLUSIONS: Topical 5% TA solution is as effective as 3% HQ cream in melasma with enhanced patient satisfaction.

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Available abstract

BACKGROUND AND AIMS: Melasma is a common, relapsing, acquired, symmetrical facial hypermelanosis with no universally effective therapy. Hydroquinone (HQ) is considered the gold standard in the treatment of melasma till date. Tranexamic acid (TA) is an upcoming molecule being explored in melasma therapy and has shown optimistic results in preliminary trials. This study aimed to compare the efficacy of topical 5% TA solution with 3% HQ cream in the treatment of melasma in Indian skin. MATERIAL AND METHODS: -value of <0.05 was considered to be statistically significant. RESULTS: value = 0.03) in view of lesser adverse effects. CONCLUSIONS: Topical 5% TA solution is as effective as 3% HQ cream in melasma with enhanced patient satisfaction.

Key concepts: Melasma, Medicine, Dermatology, Adverse effect, Tranexamic acid, Randomized controlled trial, Patient satisfaction, Internal medicine

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A randomized controlled study comparing the efficacy of topical 5% tranexamic acid solution versus 3% hydroquinone cream in melasma — Research Paper | ScholarLens