2015•Journal of Pigmentary DisordersOpen access

Tranexamic Acid in Melasma: A Review

Shital Poojary, Khushboo Minni

Abstract

Melasma is a localized, chronic acquired hypermelanosis of the skin. Despite several treatments available, melasma can often be refractory to treatment. Also recurrences are common. Tranexamic acid is a new addition in treatment of melasma and is effective in dosage of 250 mg BD for atleast 4 to 8 weeks. Tranexamic acid acts mainly via the plasminogen activator-plasmin system to prevent UV radiation induced pigmentation in melasma. This article reviews the mechanism of action of tranexamic acid in melasma and current evidence in literature for use of tranexamic acid in melasma.

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Key concepts: Melasma, Tranexamic acid, Medicine, Dermatology, Plasmin, Pharmacology, Surgery, Blood loss