1997•PubMedRequires access

N-aralkyl substitution of 2-aminoindans. Synthesis and their inotropic and chronotropic activity in isolated guinea pig atria.

J A Pérez, J.N. Dominguez, Jorge Ángel, Zandra Perez, Margarita Salazar-Bookaman, Helena Acosta, Jaime Charris

Abstract

Amino substitution of rigid forms of dopamine 4,5-dihydroxy-2-aminoindan and 5,6-dihydroxy-2-aminoindan with aralkyl functionalities were carried out to investigate the role of such structural modifications upon cardiac inotropic-chronotropic activity. Compounds synthesized demonstrated a modest inotropic selectivity, while one of them, described as 5,6-dihydroxy-N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-aminoindan hydrobromide 17, showed a marked inotropic action on isolated heart tissue.

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Key concepts: Chronotropic, Inotrope, Chemistry, Selectivity, Pharmacology, Hydrobromide, Guinea pig, Internal medicine