Li‐Ben Wang, Chu‐Yi Yu, Zhi‐Tang Huang
Abstract
Heterocyclic ketene aminals 1 react with chloroacetonitrile in the presence of sodium hydride to give the N-alkylated products 2. The disubstituted heterocyclic ketene aminal 3 react also with the same reagent to give the N-alkylated product 4.
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Heterocyclic ketene aminals 1 react with chloroacetonitrile in the presence of sodium hydride to give the N-alkylated products 2. The disubstituted heterocyclic ketene aminal 3 react also with the same reagent to give the N-alkylated product 4.
Key concepts: Ketene, Aminal, Chemistry, Sodium hydride, Reagent, Alkylation, Organic chemistry, Medicinal chemistry