2005•Bioorganic & Medicinal Chemistry LettersOpen access

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors

Yan Shi, Jing Zhang, Philip D. Stein, Mengxiao Shi, Stephen P. O’Connor, Sharon N. Bisaha, Chi Li, Karnail S. Atwal, Gregory S. Bisacchi, Doree F. Sitkoff, Andrew T. Pudzianowski, Eddie C. Liu, Karen S. Hartl, Steven M. Seiler, Sonia Youssef, Thomas E. Steinbacher, William A. Schumacher, Alan R. Rendina, Jeffrey M. Bozarth, Tara L. Peterson, Ge Zhang, Robert Zahler

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Key concepts: Ketene, Aminal, Chemistry, Lactam, Thiourea, Stereochemistry, Orally active, Combinatorial chemistry