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2008•2008 Solid-State, Actuators, and Microsystems Workshop Technical DigestOpen access

POLYMER-BASED MICROSYSTEM FOR MECHANICAL CHARACTERIZATION OF CELLS

Markus Gnerlich, W.-Y. Zhang, Henry J. Donahue, Arkady Voloshin, Svetlana Tatić-Lučić

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Abstract

A BioMEMS platform has been developed to measure the mechanical compliance of live biological cells.It integrates a Vshaped electrothermal actuator (ETA) array, a force sensor, a displacement sensor, a thermal sensor, and a cell-positioning system in a single chip.By compressing a cell and measuring the reaction force with a biocompatible polymer-based system, the mechanical compliance can be measured without damaging the cell.Here, we present the initial characterizations of the integrated sensors and actuators, as well as temperature measurements during actuation in liquid environments including cell medium.

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A BioMEMS platform has been developed to measure the mechanical compliance of live biological cells.It integrates a Vshaped electrothermal actuator (ETA) array, a force sensor, a displacement sensor, a thermal sensor, and a cell-positioning system in a single chip.By compressing a cell and measuring the reaction force with a biocompatible polymer-based system, the mechanical compliance can be measured without damaging the cell.Here, we present the initial characterizations of the integrated sensors and actuators, as well as temperature measurements during actuation in liquid environments including cell medium.

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Available abstract

A BioMEMS platform has been developed to measure the mechanical compliance of live biological cells.It integrates a Vshaped electrothermal actuator (ETA) array, a force sensor, a displacement sensor, a thermal sensor, and a cell-positioning system in a single chip.By compressing a cell and measuring the reaction force with a biocompatible polymer-based system, the mechanical compliance can be measured without damaging the cell.Here, we present the initial characterizations of the integrated sensors and actuators, as well as temperature measurements during actuation in liquid environments including cell medium.

Key concepts: Microsystem, Actuator, Materials science, Biocompatible material, Displacement (psychology), Characterization (materials science), Polymer, Lab-on-a-chip

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