ANTIMICROBIAL ACTIVITY OF DIFFREENT EXTRACTS OF GLYCYRRHIZ GLABRA

The present study was done to analyze the antimicrobial activity of different extracts of Glycyrrhiza glabra. Medicinal plants serve as potent antimicrobial agents. Here, the ethanolic, methanolic, choloroform, ethyl acetate and aqueous extracts of Glycyrrhiza glabra were examined for their antibacterial activity against grampositive and gram negative bacterial strains using disk diffusion technique. Further, Minimum inhibitory concentrations (MICs) of the extracts were also determined using microbroth dilution test. It was observed that all the extracts of Glycyrrhiza glabra possess high antimicrobial potential against maximum test bacteria used. Maximum zone of inhibition was observed for chloroform extract of Glycyrrhiza glabra against Enterococcus faecalis ATCC 29212 (29 mm) with MIC 10.4 µg/ml and MLC 41.7 µg/ml among gram positive bacteria. Whereas, among gram negative bacteria maximum zone of inhibition was observed in case of methanolic extract against Escherichia coli ATCC 11840 (20 mm) with MIC 20.8 µg/ml and MLC 83.3 µg/ml.