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2019•Natural Product ResearchOpen access

Atalantums H-K from the peels of Atalantia monophylla and their cytotoxicity

Aonnicha Sombatsri, Yutthapong Thummanant, Thurdpong Sribuhom, Paweena Wongphakham, Thanaset Senawong, Chavi Yenjai

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Abstract

Four new benzoyltyramines, atalantums H-K (1–4) and seven known compounds were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC50 values ranging from 16-25 μg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC50 values ranging from 15-18 μg/mL and an IC50 value of 80.20 μg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.

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What this paper is about

Four new benzoyltyramines, atalantums H-K (1–4) and seven known compounds were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC50 values ranging from 16-25 μg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC50 values ranging from 15-18 μg/mL and an IC50 value of 80.20 μg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.

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Available abstract

Four new benzoyltyramines, atalantums H-K (1–4) and seven known compounds were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC50 values ranging from 16-25 μg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC50 values ranging from 15-18 μg/mL and an IC50 value of 80.20 μg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.

Key concepts: Cytotoxicity, Vero cell, HeLa, IC50, Chemistry, Cell culture, Stereochemistry, In vitro

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