2010•Pharmaceutical Sciences EncyclopediaRequires access

Immunogenicity of Therapeutic Proteins

Suzanne Hermeling, Daan J.A. Crommelin, Huub Schellekens, Wim Jiskoot

Abstract

Abstract The introduction of recombinant DNA techniques has made possible to produce proteins on a large scale. These protein therapeutics are potentially immunogenic, inducing antibodies in patients after a certain period of treatment. This article gives an overview of the current knowledge about the immunogenicity of therapeutic proteins.

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Key concepts: Immunogenicity, Human proteins, Computational biology, Recombinant DNA, Antibody, Biology, Immunology, Medicine