Stephanie Scales, et al. et al.
Abstract
Abstract An electron‐withdrawing group in 2‐position of the pyrazine directs the nucleophilic attack preferentially to the 5‐position, whereas electron‐donating groups in 2‐position promote the substitution at the 3‐position.
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Abstract An electron‐withdrawing group in 2‐position of the pyrazine directs the nucleophilic attack preferentially to the 5‐position, whereas electron‐donating groups in 2‐position promote the substitution at the 3‐position.
Key concepts: Chemistry, Nucleophilic aromatic substitution, Regioselectivity, Substitution reaction, Nucleophilic substitution, Radical-nucleophilic aromatic substitution, Medicinal chemistry, Electrophilic aromatic substitution