Comparative efficacy of topical 4% hydroquinone vs. 4% hydroquinone plus 10% mandelic acid in the treatment of melasma

Objective To compare the efficacy of topical 4% hydroquinone with combination of 4% hydroquinone and 10% mandelic acid serum in the treatment of melasma. Methods This comparative study was conducted from 1st June, 2017 to 31st December, 2017 at dermatology outpatient (OPD). The trial included 100 patients age ranging from 16 to 50 years, having facial melasma. Patients were randomized to receive topical 4% hydroquinone (group I) or 4% hydroquinone along with 10% mandelic acid (group II). Efficacy was determined at week 24. Results Both groups showed improvement in melasma; however, group II showed better results. At final follow-up, 50% patients in group II showed a response of >50%; however, in group I, only 20% patients showed >50% response. Conclusion The combination of 4% hydroquinone with 10% mandelic acid is more effective in melasma as compared to conventional topical treatment.