Pathomorphological and Immuno histochemical Findings of Different Types of Cutaneous Papillomas in Bovines

The materials for present study included the samples suspected for neoplasia of bovine origin submitted to the Department of Veterinary Pathology, College of Veterinary Science, Tirupati by the Department of Veterinary Surgery and Radiology and Veterinary Dispensaries in and around Tirupati.Samples were also collected from animals necropsied in the Department of Veterinary Pathology.Particulars like breed, sex, location, shape, colour and consistency of growths were recorded. HistopathologyRepresentative tissue samples collected were fixed in 10 percent neutral buffered formalin and processed routinely for histopathological examination.Sections of 4-6 µ thickness were made and stained with Haematoxylin and Eosin. ABSTRACTBovine Papillomatosis (BP) is a cutaneous viral disease of cattle caused by Bovine Papilloma Virus (BPV).Out of 57 tumor samples, 12 were diagnosed as papillomas or warts (21.05%) of which ten were collected from cattle and two from buffaloes.The animals had either generalized or solitary cutaneous growths in different parts of the body.Grossly, the growths were solitary or multiple, pinkish to greyishwhite in colour, 0.5 to 10 cm in diameter, sessile or pedunculated and hard in consistency.Histopathologically, squamous papilloma, viral papilloma (papillomatosis), fibropapilloma and angiokeratoticacanthomatous papilloma were noticed.Immuno histo chemically, PCNA expression in papilloma was observed predominantly in the cells of basal and parabasal layers of epidermis.The PCNA antibodies were very useful marker to detection of cellular proliferation in the bovine cutaneous papillomas