2018•Leukemia & lymphoma/Leukemia and lymphomaRequires access

Reduction of hospitalization and transfusion support in patients with acute promyelocytic leukemia treated with arsenic trioxide plus all-trans retinoic acid compared to chemotherapy plus all-trans retinoic acid

Francesco Autore, Patrizia Chiusolo, Federica Sorà, Sabrina Giammarco, Luca Laurenti, Idanna Innocenti, Elisabetta Metafuni, Nicola Piccirillo, Livio Pagano, Andrea Bacigalupo, Giuseppe Leone, Simona Sica

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Abstract

Acute promyelocytic leukemia (APL) is a variant of AML characterized by t(15;17). The discovery of the molecular pathogenesis has led to the first targeted therapy for acute leukemia: all-trans ret...

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Key concepts: Arsenic trioxide, Acute promyelocytic leukemia, Retinoic acid, Medicine, Chemotherapy, Tretinoin, Arsenic, Internal medicine