Gastric mucosa structure in patients with different serum pepsinogen levels and ratios

Purpose of the study. Determine the gastric mucosa Structure in patients with different serum pepsinogen levels and ratios. Material and methods. 801 people (387 men, 414 women) underwent clinical examination and determination of pepsinogen-1, pepsinogen-2 and serum anti-Helicobacter pylori antibodies using GastroPanel (Biokhit, Finland). 161 patients with different levels of atrophy determined by serological screening method underwent a fibroesophagogastroduodenoscopy (Olimpus-10) with biopsy and subsequent morphological examination of the gastric mucosa performed using a visual analogue scale according to the Sydney Staging System. 107 patients had morphometry of the gastric mucosa with the determination of the number of central, parietal and mucoid cells. Results. The prevalence of severe atrophic gastritis in the stomach accounted for 10.9%. H. pylori was detected in 90.0% of the subjects. The morphological study showed atrophy in 94.4–95.8% of subjects with atrophic gastritis of the corpus mucosa of the stomach as defined by serological testing. Conclusions. Atrophy of the stomach mucous membrane as determined by morphological examination was prevalent in patients with severe atrophic gastritis of the corpus mucosa of the stomach, diagnosed using the method for determining serum pepsinogen levels.