Expression of p21 and p16 proteins in different gastritis and gastric cancer tissues and the clinical significance

Objective To explore the relationship between different types of gastritis and gastric cancer.Methods The expression of p21 and p16 proteins in varioliform gastritis, non-atrophic gastritis, atrophic gastritis,and gastric cancer was detected by immunohistochemistry. The results were compared. Results The positive rate of p21 protein expression in non-atrophic gastritis, atrophic gastritis, varioliform gastritis, gastric cancer was 0, 22.5%,35.0%, 60.0%, respectively, which was significantly higher in varioliform gastritis than non-atrophic gastritis, but significantly lower than gastric cancer(P0.05). The positive rate of p16 protein expression in non-atrophic gastritis, atrophic gastritis, varioliform gastritis, gastric cancer was 90.0%, 50.0%, 45.0%, 17.5%, respectively, which was significantly lower in varioliform gastritis than non-atrophic gastritis, but significantly higher than gastric cancer(P0.01).No significant differences were noted between varioliform gastritis and atrophic gastritis. Conclusion Both p21 and p16 proteins may be involved in the evolution of varioliform gastritis to gastric cancer.