Highly enantioselective Michael addition of α‐nitroacetate to α,β‐unsaturated pyrazolamide catalyzed by a bifunctional squaramide

A highly enantioselective (91- > 99% ee) Michael addition of α-nitroacetate to α,β-unsaturated pyrazolamide was developed in the presence of a bifunctional squaramide. Satisfactory isolated yields (42%-99%) have been achieved with a wide range of α,β-unsaturated pyrazolamides, albeit acceptor of this type displayed poor reactivity in the precedent reports. The adducts resulting from this protocol are useful synthetic intermediates for further synthetic modification.