2020•Advanced Synthesis & CatalysisRequires access

Recent Advances in Squaramide‐Catalyzed Asymmetric Mannich Reactions

Xi‐Qiang Hou, Da‐Ming Du

Abstract

Abstract Bifunctional squaramides as a branch of organo‐catalysts showed powerful strategies in the art of asymmetric synthesis, and they have been proved to be highly efficient and versatile catalysts for constructing complex molecular structures and chiral biologically active compounds. In this review, we summarized recent advances in bifunctional squaramide‐catalyzed asymmetric Mannich reactions. magnified image

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Available abstract

Key concepts: Squaramide, Bifunctional, Chemistry, Mannich reaction, Catalysis, Organocatalysis, Enantioselective synthesis, Combinatorial chemistry