2018•Murray State's Digital Commons (Murray State University)Requires access
Effect of Delivery System of Photosensitizer in Photodynamic Therapy and Tumor
Jonathan R. Ballard
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Abstract
The effect of Photofrin photosensitizer encapsulated in liposomal delivery vehicles was studied by observing tumor response after conducting photodynamic therapy (PDT). PDT involves the administration of a tumor-localizing photosensitizing agent followed by activation of the agent by light of a specific wavelength. The therapy results in a sequence of photochemical and photobiological processes that cause irreversible damage to tumor tissue. Three liposomal delivery vehicles were chosen to deliver the photosensitizer in vivo: DDPC/cholesterol, DMPC/ HPC and stealth liposomes. Selective tumor destruction was observed with each delivery vehicle upon observation of tumor response.