P2582Impact of left circumflex coronary artery disease on outcomes after successful transcatheter mitral valve repair using the MitraClip for ischaemic functional mitral regurgitation

Introduction: The extent of coronary artery disease (CAD) influences the development of ischaemic functional mitral regurgitation (I-FMR). We hypothesized that the type of culprit vessel affected results and outcomes of transcatheter mitral valve repair (TMVR) using the MitraClip®. Purpose: We sought to assess clinical predictors of adverse outcomes of TMVR in patients with I-FMR, focusing on the extent of CAD. Methods: Out of 314 patients with functional mitral regurgitation who underwent TMVR from September 2009 to August 2015, 154 patients with I-FMR were enrolled in this study, after excluding patients with non-ischaemic origin (n=126), procedural failure (MR >2+ at discharge; n=19), and missing completion of angiographic confirmation (n=15). We analyzed patient characteristics to elucidate predictors of the composite endpoint of repeat mitral valve intervention and all-cause mortality. The prevalence of CAD in the 154 I-FMR patients was as follows: left anterior descending (LAD) n=129 (84%), left circumflex (LCX) n=79 (51%), right coronary artery (RCA) n=96 (62%).