Comparison of posterior capsule opacification after implantation of two different intraocular lenses: a Meta-analysis

AIM: To compare posterior capsule opacification(PCO)after phacoemulsification cataract surgery with implantation of two different hydrophobic acrylic intraocular lenses(IOLs). METHODS: Such databases as PubMed(1980-Sep 2015),CBM(1990-Sep 2015),VIP(1989-Sep 2015),CNKI(1990-Sep 2015)and WanFang Data(1990-Sep 2015)were searched to collect the randomized controlled trials(RCTs)about AcrySof 3-piece IOL vs Sensar 3-piece IOL for PCO or incidence of Nd:YAG laser capsulotomy.According to the inclusion and exclusion criteria,two reviewers independently screened the literatures,extracted data and assessed the quality of the included studies,then Meta-analysis was conducted using RevMan 5.2 software. RESULTS: A total of 5 RCTs involving 1 036 eyes(AcrySof group: 553 eyes, Sensar group: 483 eyes)were included, with a follow-up duration of 6mo～2a.The results of Meta-analysis showed that:(1)the incidence of PCO was significantly lower in AcrySof group than that in Sensar group(OR=0.67,95%CI:0.45～0.99,P=0.04);(2)the incidence of Nd:YAG laser capsulotomy after surgeries was similar between AcrySof group and Sensar group(OR=0.57,95%CI:0.32～1.02,P=0.06);(3)in an above 2a long-term follow-up subgroup analysis, AcrySof group indicated a significantly lower incidence of PCO(OR=0.60,95%CI:0.40～0.91,P=0.02), while the Nd:YAG laser capsulotomy incidence was similar between the two groups(OR=0.60,95%CI:0.33～1.09,P=0.09). CONCLUSION: AcrySof 3-piece IOL seems to have a stronger preventive effect on PCO than Sensar 3-piece IOL. For the quantity limitation of the included studies,this conclusion still needs to be further proved by more high-quality RCTs.