ScholarLens Back to search
2018•Journal of Drug Delivery and TherapeuticsOpen access

BRINE SHRIMP LETHALITY BIOASSAY OF BOUGAINVILLEA GLABRA

Sudheer Kumar Dokuparthi, G. J. Lakshmi, A Anjana, Syed F Fatima, P Ashwini, Suresh Kandagatla, Suthakaran Raj

Open full text 2 citations

Abstract

The crude methanolic extract of Bougainvillea glabra leaves has been investigated for the evaluation of the cytotoxic activity.All the extracts of the plant were screened for their cytotoxicity by using brine shrimp nauplii (Artemia salina) lethality bioassay.The toxicity was assessed in terms of LC 50 (lethality concentration), 10 nauplii were taken into three replicates of each concentration of the methanolic leaf extract.Brine shrimps were checked for the mortality during 24 hrs period, surviving brine shrimps were counted and LC 50 was evaluated.The results showed that all the extracts were showing potent toxicity to the nauplii.The LC 50 values were compared to the standard potassium dichromate.It indicates that the extracts are toxic even at low doses.Further investigation is needed to study the acute and subacute toxicity of the extracts for its safe application to the humans.

Open-access reader

About this research paper

What this paper is about

The crude methanolic extract of Bougainvillea glabra leaves has been investigated for the evaluation of the cytotoxic activity.All the extracts of the plant were screened for their cytotoxicity by using brine shrimp nauplii (Artemia salina) lethality bioassay.The toxicity was assessed in terms of LC 50 (lethality concentration), 10 nauplii were taken into three replicates of each concentration of the methanolic leaf extract.Brine shrimps were checked for the mortality during 24 hrs period, surviving brine shrimps were counted and LC 50 was evaluated.The results showed that all the extracts were showing potent toxicity to the nauplii.The LC 50 values were compared to the standard potassium dichromate.It indicates that the extracts are toxic even at low doses.Further investigation is needed to study the acute and subacute toxicity of the extracts for its safe application to the humans.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The crude methanolic extract of Bougainvillea glabra leaves has been investigated for the evaluation of the cytotoxic activity.All the extracts of the plant were screened for their cytotoxicity by using brine shrimp nauplii (Artemia salina) lethality bioassay.The toxicity was assessed in terms of LC 50 (lethality concentration), 10 nauplii were taken into three replicates of each concentration of the methanolic leaf extract.Brine shrimps were checked for the mortality during 24 hrs period, surviving brine shrimps were counted and LC 50 was evaluated.The results showed that all the extracts were showing potent toxicity to the nauplii.The LC 50 values were compared to the standard potassium dichromate.It indicates that the extracts are toxic even at low doses.Further investigation is needed to study the acute and subacute toxicity of the extracts for its safe application to the humans.

Key concepts: Bioassay, Lethality, Brine shrimp, Biology, Chemistry, Toxicology, Environmental science, Fishery

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
BRINE SHRIMP LETHALITY BIOASSAY OF BOUGAINVILLEA GLABRA — Research Paper | ScholarLens