2018•Epidemiology and Vaccinal PreventionOpen access

Immunogenic Properties of Cell Wall Preparations of Francisella tularensis Different Subspecies in Experimental Tularemia

А. В. Корнева, В. Б. Николаев, T. А. Ivanova, В. И. Дубровина, G. B. Mukhturgin, E. Yu. Markov, Т. П. Старовойтова, А. В. Мазепа, Т. Т. Шкаруба, С. В. Балахонов

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Abstract

Immunogenic properties of cell wall (CW) preparations of Francisella tularensis four subspecies are investigated. It is shown that the preparations from F. tularensis urea lysates are not toxic for experimental animals. Besides, CW of F. tularensis А-61 subsp. mediasiatica and F. tularensis B-399 A-Cole subsp. tularensis possess immunogenic activity in experimental tularemia caused by F. tularensis 306 subsp. holarctica.

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Key concepts: Francisella tularensis, Tularemia, Microbiology, Subspecies, Biology, Francisella, Virology, Virulence