Francisella tularensis : biology, pathogenicity, epidemiology, and biodefense

Preface. 1. Tularemia: History, Epidemiology, Pathogen Physiology, and Clinical Manifestations: Anders Sjostedt. 2. Molecular Ecology, Epidemiology and Evolution of Francisella: Paul Keim, Anders Johannson, and David Wagner. 3. Genetics and Genetic Manipulations in Francisella Tularensis: Tom Zahrt and Dara Frank. 4. Francisella Tularensis: Genomics and Proteomics: Richard Titball and Joseph Petrosino. 5. The Francisella Pathogenicity Island: Francis E. Nano and Crystal Schmerk. 6. Molecular and Genetic Bases of Pathogenesis in Francisella Tularensis: Jeffrey R. Barker and Karl E. Klose. 7. Uptake and Intracellular Fate of Francisella Tularensis in Human Macrophages: Daniel Clemens and Marcus A. Horwitz. 8. Type II Secretion and Type IV Pili of Francisella: Tina Guina and Ake Forsberg. 9. The Structure and Function of Francisella LPS: John Gunn and Robert Ernst. 10. Francisella Tularensis Activation of the Inflammasome: David S. Weiss, Thomas Henry, and Denise M. Monack. 11. Animal Models of Francisella Tularensis Infection: C. Rick Lyons and Terry Wu. 12. Mucosal Immunopathogenesis of Francisella Tularensis: Dennis W. Metzger, Chandra Shekhar Bakshi, and Girish Kirimanjeswara. 13. Innate and Adaptive Immunity to Francisella: Karen L. Elkins, Siobhan C. Cowley, and Catharine M. Bosio. 14. Vaccines against Francisella Tularensis: J. Wayne Conlan and Petra C.F. Oyston. 15. Pneumonic Tularemia on Martha's Vineyard: Clinical, Epidemiologic and Ecological Characteristics: Bela T. Matyas, Henry S. Nieder, Sam R. Telford III. 16. New Approaches to Diagnosis and Therapy of Tularemia: Arne Tarnvik and May Chu. 17. Biosafety and Selectable Markers: Richard W. Titball, Anders Sjostedt, Martin S. Pavelka Jr., and Francis Nano. Index of Contributors