Modified poisoning severity score for early prognostic evaluation in acute paraquat poisoning

Objective To study the applied value of modified poisoning severity score (PSS) for early prognostic evaluation in acute paraquat poisoning. Methods Thirty-seven patients with acute paraquat poisoning from June 2013 to June 2016 were enrolled. The PSS score, the modified PSS score, the acute physiology and the chronic health status ? score (APACHE ?) of the patients were calculated. The relationship between modified PSS and APACHE ? was analyzed. Also the factors that affect outcome were analyzed by logistic regression analysis. The work characteristic curve (ROC curve) of the PSS, the modified PSS and the APECH ? were drawn and compared. Results There was a positive correlation between the risk of death and admission time, poisonous dose, the concentration of urine paraquat, and white blood cell count (P<0.05). There was a significant correlation between the modified PSS and the APACHE ?(P<0.0001). The immediate PSS score, the modified PSS score, and the APACHE ? score were significant for the prognosis of patients with acute paraquat poisoning. The area under the curve (AUC) was in turn 0.774, 0.788, 0.799. Among them, the best bound of the modified PSS score was 6.5 (when the score is greater than 6.5, the risk of death is higher). Further comparison of the area under the three curves showed that there was no significant difference in the area under the ROC curve between the three scores in predicting the prognosis of death [P=0.7633(PSS-DPSS), P=0.7791(PSS-APACHE ?), P=0.8918(DPSS-APACHE ?)]. Conclusion Modified PSS is helpful in early predicting the prognosis of acute paraquat poisoning. DOI: 10.11855/j.issn.0577-7402.2018.04.13