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2018•Obstetrical & Gynecological SurveyOpen access

Gonadotrophins Versus Clomifene Citrate With or Without Intrauterine Insemination in Women With Normogonadotropic Anovulation and Clomifene Failure (M-OVIN): A Randomized, Two-by-Two Factorial Trial

Nienke S Weiss, Marleen J. Nahuis, Esmée M Bordewijk, Jurjen E. Oosterhuis, Jesper M J Smeenk, Annemieke Hoek, Frank J. Broekmans, Kathrin Maria Fleischer, Jan Peter de Bruin, Eugenie M. Kaaijk, Joop S.E. Laven, Dave J. Hendriks, Marie H Gerards, Ilse A.J. van Rooij, Petra Bourdrez, Judith Gianotten, Carolien A.M. Koks, Cornelis Bavo Lambalk, Peter G.A. Hompes, Fulco van der Veen, Ben W. Mol, Madelon van Wely

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Abstract

(Abstracted from Lancet 2018;391:758–765) Clomifene citrate has long been used as a first-line ovulation induction agent for women wishing to conceive who have normogonadotropic anovulation (absent or irregular ovulation). Women who ovulate but do not conceive after several cycles with clomifene citrate are usually switched to ovulation induction with gonadotrophins, with or without intrauterine insemination.

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(Abstracted from Lancet 2018;391:758–765) Clomifene citrate has long been used as a first-line ovulation induction agent for women wishing to conceive who have normogonadotropic anovulation (absent or irregular ovulation). Women who ovulate but do not conceive after several cycles with clomifene citrate are usually switched to ovulation induction with gonadotrophins, with or without intrauterine insemination.

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Available abstract

(Abstracted from Lancet 2018;391:758–765) Clomifene citrate has long been used as a first-line ovulation induction agent for women wishing to conceive who have normogonadotropic anovulation (absent or irregular ovulation). Women who ovulate but do not conceive after several cycles with clomifene citrate are usually switched to ovulation induction with gonadotrophins, with or without intrauterine insemination.

Key concepts: Clomifene, Ovulation induction, Anovulation, Medicine, Ovulation, Intrauterine insemination, Gynecology, Insemination

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Gonadotrophins Versus Clomifene Citrate With or Without Intrauterine Insemination in Women With Normogonadotropic Anovulation and Clomifene Failure (M-OVIN): A Randomized, Two-by-Two Factorial Trial — Research Paper | ScholarLens