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Antioxidant Activity in vitro of Chroogomphis rutilus Flavonoids

Haiyue Zhang, Xue Yang, Zhen Li, Yu Hao

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Abstract

The extraction and antioxidant activity in vitro of flavonoids from Chroogomphis rutilus was investi-gated. The extraction process was optimized using response surface methodology. The evaluation of antioxidant activity was carried out by DPPH radical and hydroxyl radical scavenging assays in comparison to VC. The opti-mum extraction conditions were determined as 83%, 15∶1(mL/g), 2.5 h and 85℃for ethanol concentration, sol-vent-to-solid ratio, extraction time and temperature, respectively. The experimentally observed on extraction efficiency of flavonoids under the optimized conditions was 6.72%. In DPPH radical and hydroxyl radical scav-enging assays, the IC50 of the flavonoids from Chroogomphis rutilus were 0.01,0.17 mg/mL, were higher than that of VC. These results showed that flavonoids of Chroogomphis rutilus had strong antioxidant activity in vitro.

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What this paper is about

The extraction and antioxidant activity in vitro of flavonoids from Chroogomphis rutilus was investi-gated. The extraction process was optimized using response surface methodology. The evaluation of antioxidant activity was carried out by DPPH radical and hydroxyl radical scavenging assays in comparison to VC. The opti-mum extraction conditions were determined as 83%, 15∶1(mL/g), 2.5 h and 85℃for ethanol concentration, sol-vent-to-solid ratio, extraction time and temperature, respectively. The experimentally observed on extraction efficiency of flavonoids under the optimized conditions was 6.72%. In DPPH radical and hydroxyl radical scav-enging assays, the IC50 of the flavonoids from Chroogomphis rutilus were 0.01,0.17 mg/mL, were higher than that of VC. These results showed that flavonoids of Chroogomphis rutilus had strong antioxidant activity in vitro.

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Available abstract

The extraction and antioxidant activity in vitro of flavonoids from Chroogomphis rutilus was investi-gated. The extraction process was optimized using response surface methodology. The evaluation of antioxidant activity was carried out by DPPH radical and hydroxyl radical scavenging assays in comparison to VC. The opti-mum extraction conditions were determined as 83%, 15∶1(mL/g), 2.5 h and 85℃for ethanol concentration, sol-vent-to-solid ratio, extraction time and temperature, respectively. The experimentally observed on extraction efficiency of flavonoids under the optimized conditions was 6.72%. In DPPH radical and hydroxyl radical scav-enging assays, the IC50 of the flavonoids from Chroogomphis rutilus were 0.01,0.17 mg/mL, were higher than that of VC. These results showed that flavonoids of Chroogomphis rutilus had strong antioxidant activity in vitro.

Key concepts: DPPH, Rutilus, Antioxidant, Chemistry, Extraction (chemistry), Hydroxyl radical, Ethanol, In vitro

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