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2018•Trends in ImmunotherapyOpen access

Transient effectiveness of dapsone for skin lesions in a patient with discoid lupus erythematosus

Naoya Mikita, Fukumi Furukawa

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Abstract

Dapsone is a synthetic sulfone preparation and is second-line treatment for cutaneous lupus erythematosus (CLE) including discoid LE (DLE). This report describes a patient with DLE, which was improved by dapsone quickly but the recurrence was noted. Oral administration of prednisolone (5 mg / day) was required but the complete healing was very difficult. In this report, we will discuss the effectiveness and limitation of dapsone for patients with DLE and the mechanisms of action.

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What this paper is about

Dapsone is a synthetic sulfone preparation and is second-line treatment for cutaneous lupus erythematosus (CLE) including discoid LE (DLE). This report describes a patient with DLE, which was improved by dapsone quickly but the recurrence was noted. Oral administration of prednisolone (5 mg / day) was required but the complete healing was very difficult. In this report, we will discuss the effectiveness and limitation of dapsone for patients with DLE and the mechanisms of action.

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Available abstract

Dapsone is a synthetic sulfone preparation and is second-line treatment for cutaneous lupus erythematosus (CLE) including discoid LE (DLE). This report describes a patient with DLE, which was improved by dapsone quickly but the recurrence was noted. Oral administration of prednisolone (5 mg / day) was required but the complete healing was very difficult. In this report, we will discuss the effectiveness and limitation of dapsone for patients with DLE and the mechanisms of action.

Key concepts: Dapsone, Discoid lupus erythematosus, Medicine, Dermatology, Prednisolone, Lupus erythematosus, Sulfone, Surgery

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Transient effectiveness of dapsone for skin lesions in a patient with discoid lupus erythematosus — Research Paper | ScholarLens