2018Journal of Dr. YSR University of Health Sciences.Open access

Atypical presentation of chronic myeloid leukemia with visual disturbance

Rachana Chennamaneni, Stalin Bala, Sadashivudu Gundeti, Meher Lakshmi

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Abstract

Chronic myeloid leukemia (CML) is a clonal hematopoietic disorder characterized by a reciprocal translocation between chromosome 9 and 22 resulting in bcr-abl1 fusion gene. Patients usually present with symptoms of anemia, splenomegaly, and hyperleukocytosis. Initial presentation with visual disturbance, without other symptoms, is rare in CML. No specific treatment has been described for ocular lesions in leukemia. Treating the underlying malignancy would aid in resolution of the symptoms. We report a case of CML presenting with retinal hemorrhages.

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What this paper is about

Chronic myeloid leukemia (CML) is a clonal hematopoietic disorder characterized by a reciprocal translocation between chromosome 9 and 22 resulting in bcr-abl1 fusion gene. Patients usually present with symptoms of anemia, splenomegaly, and hyperleukocytosis. Initial presentation with visual disturbance, without other symptoms, is rare in CML. No specific treatment has been described for ocular lesions in leukemia. Treating the underlying malignancy would aid in resolution of the symptoms. We report a case of CML presenting with retinal hemorrhages.

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Available abstract

Chronic myeloid leukemia (CML) is a clonal hematopoietic disorder characterized by a reciprocal translocation between chromosome 9 and 22 resulting in bcr-abl1 fusion gene. Patients usually present with symptoms of anemia, splenomegaly, and hyperleukocytosis. Initial presentation with visual disturbance, without other symptoms, is rare in CML. No specific treatment has been described for ocular lesions in leukemia. Treating the underlying malignancy would aid in resolution of the symptoms. We report a case of CML presenting with retinal hemorrhages.

Key concepts: Medicine, Myeloid leukemia, Visual Disturbance, Presentation (obstetrics), Chromosomal translocation, Anemia, Malignancy, Dermatology

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