ScholarLens Back to search
2020•Japanese Journal of Oral & Maxillofacial SurgeryOpen access

A case of t (11;22)(q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate

Yuki Arimura, Chiaki Yamada, Ayumi Okada, Shota YAKUSHIJI, Narumi OKAMOTO, Seiji Iida

Open full text 0 citations

Abstract

Chromosomal translocation is one of the most common types of chromosome abnormalities. Chromosomal translocation includes balanced and unbalanced translocation. However, it is difficult to detect balanced translocation because most balanced translocations have no excess or deficiency about genetic information and remain clinically asymptomatic; recently balanced translocation is related to infertility. Among balanced translocation of the 22nd and 11st, t (11;22) (q23.3;q11.2) balanced translocation is considered representative. Generally, in balanced translocation, it is thought that cases with abnormal phenotypes such as malformation are rare. t (11;22) (q23.3;q11.2) balanced translocation has not been reported to be a risk factor for cleft lip and palate. We report a case of t (11;22) (q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate.

Open-access reader

About this research paper

What this paper is about

Chromosomal translocation is one of the most common types of chromosome abnormalities. Chromosomal translocation includes balanced and unbalanced translocation. However, it is difficult to detect balanced translocation because most balanced translocations have no excess or deficiency about genetic information and remain clinically asymptomatic; recently balanced translocation is related to infertility. Among balanced translocation of the 22nd and 11st, t (11;22) (q23.3;q11.2) balanced translocation is considered representative. Generally, in balanced translocation, it is thought that cases with abnormal phenotypes such as malformation are rare. t (11;22) (q23.3;q11.2) balanced translocation has not been reported to be a risk factor for cleft lip and palate. We report a case of t (11;22) (q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Chromosomal translocation is one of the most common types of chromosome abnormalities. Chromosomal translocation includes balanced and unbalanced translocation. However, it is difficult to detect balanced translocation because most balanced translocations have no excess or deficiency about genetic information and remain clinically asymptomatic; recently balanced translocation is related to infertility. Among balanced translocation of the 22nd and 11st, t (11;22) (q23.3;q11.2) balanced translocation is considered representative. Generally, in balanced translocation, it is thought that cases with abnormal phenotypes such as malformation are rare. t (11;22) (q23.3;q11.2) balanced translocation has not been reported to be a risk factor for cleft lip and palate. We report a case of t (11;22) (q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate.

Key concepts: Chromosomal translocation, Chromosomal rearrangement, Asymptomatic, Medicine, Genetics, Karyotype, Chromosome, Biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A case of t (11;22)(q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate — Research Paper | ScholarLens