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STUDY OF ANTINOCICEPTIVE EFFECT OF THYMUS VULGARIS AND FOENICULUM VULGARE ESSENTIAL OIL IN MOUSE

Peyman Mikaili, Mohammad Ali Mohammad Nezhady, Jalal Shayegh, Mohammad Hossein Asghari

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Abstract

In the previous studies hydro-alcoholic extract of Thymus vulgaris (Tv) has shown antinociceptive effects. In this experiment essential oil of this plant and Foeniculum vulgare used in order to determine their pain inhibitor effect by tail flick test. Mice divided into 4 groups, and two doses of each plant were used (0.01, 0.5 mg/ml) by intraperitoneal (IP) injection. The effects were studied after 30, 60 and 90 minutes after injections through tail flick test. In these doses only second dose of Tv showed antinociceptive effect, which was related to time and the most essential oil efficiency obtained in first 30 minutes. In comparison with hydro-alcoholic extract, essential oil had more efficacies. There were not significant differences between Fv and control group in these two doses.

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What this paper is about

In the previous studies hydro-alcoholic extract of Thymus vulgaris (Tv) has shown antinociceptive effects. In this experiment essential oil of this plant and Foeniculum vulgare used in order to determine their pain inhibitor effect by tail flick test. Mice divided into 4 groups, and two doses of each plant were used (0.01, 0.5 mg/ml) by intraperitoneal (IP) injection. The effects were studied after 30, 60 and 90 minutes after injections through tail flick test. In these doses only second dose of Tv showed antinociceptive effect, which was related to time and the most essential oil efficiency obtained in first 30 minutes. In comparison with hydro-alcoholic extract, essential oil had more efficacies. There were not significant differences between Fv and control group in these two doses.

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Available abstract

In the previous studies hydro-alcoholic extract of Thymus vulgaris (Tv) has shown antinociceptive effects. In this experiment essential oil of this plant and Foeniculum vulgare used in order to determine their pain inhibitor effect by tail flick test. Mice divided into 4 groups, and two doses of each plant were used (0.01, 0.5 mg/ml) by intraperitoneal (IP) injection. The effects were studied after 30, 60 and 90 minutes after injections through tail flick test. In these doses only second dose of Tv showed antinociceptive effect, which was related to time and the most essential oil efficiency obtained in first 30 minutes. In comparison with hydro-alcoholic extract, essential oil had more efficacies. There were not significant differences between Fv and control group in these two doses.

Key concepts: Foeniculum, Nociception, Essential oil, Tail flick test, Pharmacology, Chemistry, Significant difference, Traditional medicine

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STUDY OF ANTINOCICEPTIVE EFFECT OF THYMUS VULGARIS AND FOENICULUM VULGARE ESSENTIAL OIL IN MOUSE — Research Paper | ScholarLens