Meprobamate ELISA Kit

Summary Zopiclone and eszopiclone are non-benzodiazepine hypnotic agents. They are used in the treatment of insomnia in humans. Currently, eszopiclone is being marketed within the US as Lunesta by Sepracor Inc. Zopiclone, manufactured by SanofiAventis, is only available outside of the U.S. and sold under several other brand names including Imovane and Zimovane. Zopiclone and eszopiclone are currently classified schedule IV under the Controlled Substance Act in the U.S. The potential for abuse and toxicity due to overdose has been observed for both drugs.Human urine and blood remain important matrix types for testing of drugs of abuse. These two drugs can be found in both matrices as parent and metabolite forms. Data from European Medicine Agency Study 194-026 suggest concentrations of eszopiclone below 10 ng/mL in the plasma have minimal effect on the EEG and cognitive impairment. The point at which eszopiclone plasma concentrations fall to 10 ng/mL is approximately 8 hours following a 3.5 mg eszopiclone dose. This study supports the development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) for the detection of zopiclone and eszopiclone in human urine and blood.