A STUDY OF TRABECULECTOMY WITH INTRAOPERATIVE MITOMYCIN - C IN PRIMARY OPEN ANGLE GLAUCOMA

BACKGROUND \nTo study the efficacy and safety of intraoperative Mitomycin – C with trabeculectomy in management of Primary open angle \nglaucoma. To compare the results between trabeculectomy alone and trabeculectomy with intraoperative Mitomycin in terms \nof control of IOP, arrest of visual field loss, visual acuity and optic nerve head changes. \nMATERIALS AND METHODS \nThe patients were selected from the outpatient department of Ophthalmology, Nalanda Medical College, Patna. In the present \nstudy 60 eyes of 45 patients having primary open angle glaucoma were selected from the patients of attending Ophthalmology \noutpatient department. In all cases trabeculectomy was done. Cases were divided into two groups, group A and B. In group A \n30 eyes were selected randomly for trabeculectomy with intraoperative Mitomycin C In group B 30 eyes were selected randomly \nfor Trabeculectomy alone. Both eyes were operated in 15 cases. Definition of efficacy: Complete effectiveness </= 21 mmHg. \nQualified effectiveness: IOP </= 21 mmHg with single glaucoma medication. Qualified failure : IOP > 21 mmHg with or without \nglaucoma medication. Complete failure: When an eye requires a further glaucoma drainage operation. \nRESULTS \nAt 3 months follow up overall success rate in study group was 100%. Complete success in 27(90%) cases, 3(10%) qualified. \nIn control group complete success was 11(33%) and 7(23.44%) was qualified success. \nCONCLUSION \nFrom the present study with a very short follow up period it can be concluded that the use of intraoperative Mitomycin –C in \ntrabeculectomy has a better pressure lowering effect than trabeculectomy alone and it improves the success rate in high risk \ncases of primary open angle glaucoma (p 0.02943 Chi – square test).