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2017•MetallomicsRequires access

A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity

Ahmed Mohsen, Philippe Collery, Roselyne Garnotel, Bertrand Brassart, Nicolas Etique, Gilane Mohamed Sabry, Rasha Elsherif Hassan, Pierre Jeannesson, Didier Desmaële, Hamid Morjani

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Abstract

values of 168, 82, and 20 μM, respectively. A decrease in the expression of MMP-14 mRNA was observed in both cell lines, whereas the expression of MMP-2 and MMP-9 mRNA was decreased only in the MDA-MB231 cells. Data obtained for the expression of MMP-14 mRNA were confirmed via Western blotting. In fact, MMP-14 expression was decreased in the presence of GS2. Overall, these data show that GS2 is a promising compound for anti-invasive and anticancer therapy.

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What this paper is about

values of 168, 82, and 20 μM, respectively. A decrease in the expression of MMP-14 mRNA was observed in both cell lines, whereas the expression of MMP-2 and MMP-9 mRNA was decreased only in the MDA-MB231 cells. Data obtained for the expression of MMP-14 mRNA were confirmed via Western blotting. In fact, MMP-14 expression was decreased in the presence of GS2. Overall, these data show that GS2 is a promising compound for anti-invasive and anticancer therapy.

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Available abstract

values of 168, 82, and 20 μM, respectively. A decrease in the expression of MMP-14 mRNA was observed in both cell lines, whereas the expression of MMP-2 and MMP-9 mRNA was decreased only in the MDA-MB231 cells. Data obtained for the expression of MMP-14 mRNA were confirmed via Western blotting. In fact, MMP-14 expression was decreased in the presence of GS2. Overall, these data show that GS2 is a promising compound for anti-invasive and anticancer therapy.

Key concepts: Matrix metalloproteinase, Zymography, Cell culture, Blot, Cell, Fibrosarcoma, Chemistry, Molecular biology

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A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity — Research Paper | ScholarLens