2017•Antimicrobial Agents and ChemotherapyOpen access

Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching

Naoko Chiba, Somay Yamagata Murayama, Miyuki Morozumi, Satoshi Iwata, Kimiko Ubukata

Abstract

ABSTRACT Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease ( n = 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

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Key concepts: Streptococcus pneumoniae, Penicillin, Microbiology, Serotype, Penicillin resistance, Biology, Streptococcaceae, Pneumococcal infections