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Monoclonal Gammopathy Not So Benign in the Long Term

John J. Kelly

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Abstract

This study, from the highly productive group of Kyle and associates at Mayo Clinic, is an important addition to the growing body of knowledge on the significance of monoclonal gammopathies unassociated at detection with malignant plasma cell dyscrasias (PCDs). Participants were 1384 patients (average age, 72) in southern Minnesota identified over a 34-year period as having monoclonal gammopathy of undetermined significance (MGUS), according to strict laboratory criteria. About 30% of subjects developed a malignant PCD …

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What this paper is about

This study, from the highly productive group of Kyle and associates at Mayo Clinic, is an important addition to the growing body of knowledge on the significance of monoclonal gammopathies unassociated at detection with malignant plasma cell dyscrasias (PCDs). Participants were 1384 patients (average age, 72) in southern Minnesota identified over a 34-year period as having monoclonal gammopathy of undetermined significance (MGUS), according to strict laboratory criteria. About 30% of subjects developed a malignant PCD …

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Available abstract

This study, from the highly productive group of Kyle and associates at Mayo Clinic, is an important addition to the growing body of knowledge on the significance of monoclonal gammopathies unassociated at detection with malignant plasma cell dyscrasias (PCDs). Participants were 1384 patients (average age, 72) in southern Minnesota identified over a 34-year period as having monoclonal gammopathy of undetermined significance (MGUS), according to strict laboratory criteria. About 30% of subjects developed a malignant PCD …

Key concepts: Dyscrasia, Monoclonal gammopathy of undetermined significance, Monoclonal gammopathy, Medicine, Multiple myeloma, Monoclonal, Paraproteinemias, Plasma cell

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