2004•PubMedRequires access

Malignant evolution of monoclonal gammopathy of undetermined significance: analysis of 633 consecutive cases with a long term follow-up.

Dino Veneri, Haytham Aqel, Massimo Franchini, Mauro Krampera, Roberta Zanotti, Giovanni Pizzolo

Abstract

In 633 consecutive patients with monoclonal gammopathy of undetermined significance (MGUS) the probability of malignant evolution was 9, 17 and 51 % at 5, 10 and 15 years, respectively, after diagnosis. The values of monoclonal component, Bence-Jones proteinuria and erythrocyte sedimentation rate were associated with malignant transformation.

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Key concepts: Monoclonal gammopathy of undetermined significance, Bence Jones protein, Medicine, Monoclonal gammopathy, Monoclonal, Monoclonal antibody, Pathology, Internal medicine