2005•Chinese Journal of Birth Health & HeredityRequires access

Alteration and potential role of soluble fms-like tyrosine kinase receptor 1 in preeclampsia

Chun Zhang

Abstract

Objective:To investigatethe expression and location of soluble fms-like tyrosine kinase receptor 1 (sFlt-1) mRNA in placenta of preeclampsia and its role in preeclampisa pathophysiology. Methods: Semi-quantitative RT-PCR was carried out to detect the level of sFlt-1 mRNA in placental tissue of 10 preeclampsia (study group) and 10 normotensive pregnancies (control group); sFlt-1 mRNA was pinpointed by in situ hybridization. Results: The sFlt-1 mRNA was expressed in both preeclampsia and normal placenta. However, its levels were significantly higher in the former than in the latter (P0.01); sFlt-1 mRNA was located in trophocyte of placenta by in situ hybridization. Conclusion: Higher expression of sFlt-1 may be associated with the pathogenesis of preeclampsia.

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Key concepts: Preeclampsia, Placenta, In situ hybridization, Messenger RNA, Receptor tyrosine kinase, Pathogenesis, Receptor, Tyrosine kinase