Kenji Kaji, H. Nagashima, Noboru Ninoi, Toshihiko Hanada
Abstract
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By heating phenyl- and p-nitrophenyl-ω-diazoacetone in ethanol with thiourea, 4-benzyl- and 4-(p-nitrobenzyl)-2-aminothiazole were obtained in a comparatively good yield. In general, the reaction of aryl-ω-diazoacetone and thiourea may be termed a simplified method of the Hantsch's thiazole cyclization.
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By heating phenyl- and p-nitrophenyl-ω-diazoacetone in ethanol with thiourea, 4-benzyl- and 4-(p-nitrobenzyl)-2-aminothiazole were obtained in a comparatively good yield. In general, the reaction of aryl-ω-diazoacetone and thiourea may be termed a simplified method of the Hantsch's thiazole cyclization.
Key concepts: Thiourea, Thiazole, Yield (engineering), Chemistry, Aryl, Ethanol, Medicinal chemistry, Organic chemistry