Syntheses of Quinine Derivatives. XIV

Direct comparison of 2′-hydroxyquinine synthesized by Ochiai and others, with the new metabolic product of quinine obtained by treating quinine with rabbit liver as experimented by Kelseyetal., proved two compounbs to be identical, Similar treatment of quinoline with rabbit liver gives carbostyril with yield of ca 20%. No metabolic product was obtained from quinoline-N-oxide.