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2016•Evidence-Based PracticeRequires access

In patients with chronic neuropathic pain, which antidepressants are the most effective for treatment?

Andrew A. Bombardier, Michael M. Braun

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Abstract

Evidence-Based Answer Amitriptyline reduces neuropathic pain compared to placebo and is equivalent to other tricyclic antidepressants (TCAs). Selective serotonin reuptake inhibitor (SSRIs), venlafaxine, and duloxetine are also more effective than placebo for the treatment of neuropathic pain (SOR: B, systematic reviews of lower quality RCTs). There is insufficient evidence to determine if one is significantly better than the others.

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What this paper is about

Evidence-Based Answer Amitriptyline reduces neuropathic pain compared to placebo and is equivalent to other tricyclic antidepressants (TCAs). Selective serotonin reuptake inhibitor (SSRIs), venlafaxine, and duloxetine are also more effective than placebo for the treatment of neuropathic pain (SOR: B, systematic reviews of lower quality RCTs). There is insufficient evidence to determine if one is significantly better than the others.

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Available abstract

Evidence-Based Answer Amitriptyline reduces neuropathic pain compared to placebo and is equivalent to other tricyclic antidepressants (TCAs). Selective serotonin reuptake inhibitor (SSRIs), venlafaxine, and duloxetine are also more effective than placebo for the treatment of neuropathic pain (SOR: B, systematic reviews of lower quality RCTs). There is insufficient evidence to determine if one is significantly better than the others.

Key concepts: Duloxetine, Venlafaxine, Neuropathic pain, Amitriptyline, Tricyclic, Placebo, Medicine, Antidepressant

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In patients with chronic neuropathic pain, which antidepressants are the most effective for treatment? — Research Paper | ScholarLens