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2015•European Respiratory JournalRequires access

False-negative interferon-gamma release assay results in active tuberculosis: a TBNET study

Veerle de Visser, Viovanni Sotgiu, Christoph Lange, Martine G. Aabye, Marleen Bakker, Filippo Bartalesi, Kristián Brat, Cynthia Bin Eng Chee, Keertan Dheda, José Domínguez, Füsun Öner Eyüboğlu, Maha Ghanem, Delia Goletti, AsliGorek Dilektasli, Lorenzo Guglielmetti, Won‐Jung Koh, Irene Latorre, Monica Losi, Monica Polanova, Pernile Ravn, Felix C. Ringshausen, Rudolf Rumetshofer, María Luiza de Souza-Galvão, Steven Thijsen, Graham Bothamley, Aik Bossink

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Abstract

Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis, the causative bacterium of the disease. Although interferon-gamma release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis, these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity.

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What this paper is about

Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis, the causative bacterium of the disease. Although interferon-gamma release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis, these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity.

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OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis, the causative bacterium of the disease. Although interferon-gamma release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis, these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity.

Key concepts: Medicine, Tuberculosis, Mycobacterium tuberculosis, Active tuberculosis, Immunology, Interferon γ, Interferon gamma release assay, Tuberculosis diagnosis

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