ScholarLens Back to search
2014•European Respiratory JournalOpen access

False-negative interferon-γ release assay results in active tuberculosis: a TBNET study

Veerle de Visser, Giovanni Sotgiu, Christoph Lange, Martine G. Aabye, Marleen Bakker, Filippo Bartalesi, Kristián Brat, Cynthia Bin Eng Chee, Keertan Dheda, José Domínguez, Füsun Öner Eyüboğlu, Maha Ghanem, Delia Goletti, Aslı Görek Dilektaşlı, Lorenzo Guglielmetti, Won‐Jung Koh, Irene Latorre, Monica Losi, Monica Polanova, Pernille Ravn, Felix C. Ringshausen, Rudolf Rumetshofer, María Luiza de Souza-Galvão, Steven Thijsen, Graham Bothamley, Aik Bossink

Open full text 40 citations

Abstract

Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis , the causative bacterium of the disease. Although interferon-γ release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis , these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity [2]. Advanced age was the only risk factor for false-negative IGRAs in this study of active tuberculosis

Open-access reader

About this research paper

What this paper is about

Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis , the causative bacterium of the disease. Although interferon-γ release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis , these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity [2]. Advanced age was the only risk factor for false-negative IGRAs in this study of active tuberculosis

Why it matters

OpenAlex reports 40 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis , the causative bacterium of the disease. Although interferon-γ release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis , these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity [2]. Advanced age was the only risk factor for false-negative IGRAs in this study of active tuberculosis

Key concepts: Medicine, Tuberculosis, Mycobacterium tuberculosis, Active tuberculosis, Interferon γ, Immunology, Latent tuberculosis, Tuberculosis diagnosis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
False-negative interferon-γ release assay results in active tuberculosis: a TBNET study — Research Paper | ScholarLens