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THE COMBINED USE OF N(4-NITROPHENYL)-BENZAMIDINE AND BONE MARROW TRANSPLANTATION AFTER WHOLE-BODY IRRADIATION OF RATS

D.G. Zographov, I.A. Baev

Abstract

The effectiveness of combined use of N(4-nitrophenyl)benzamidine and bone marrow transplantation after single total-body irradiation of female rats was investigated using lethality and changes in body weight as measurements. The survival rate in the control group was 8%; it was 40% for that group where the animals were treated with bone marrow oniy, 52% for the chemically protected rats, and 72% for the combined treated animals. The weight changes show that the synergism of both methods is a result of a decreased radiation sensitivity of the organism by chemical radiation protection substance and a stimulation of bone marrow regeneration by the transplantation. (auth)

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Key concepts: Bone marrow, Bone marrow transplantation, Transplantation, Irradiation, Benzamidine, Stimulation, Total body irradiation, Body weight