Serum PSA And Immunohistochemical Expression Of p53 In Prostatic Specimens

Diseased prostate is a great concern in the geriatric age group.The two conditions most frequently observed in prostate are Benign Prostatic Hyperplasia (BPH) and Carcinoma prostate.The incidence of both conditions increase with advancing age and are an important growing health problem with often unpredictable clinical course.Specific molecular mechanisms are involved in the development and progression of prostate cancer as well as in BPH.A total of 70 cases were studied histologically.Out of 70 cases, 58 cases were diagnosed as Benign Prostatic Hyperplasia (BPH) and 12 cases were diagnosed as carcinoma prostate.Serum PSA levels of all the 70 cases were evaluated and correlation were made with immunohistochemical (IHC) marker p53.The difference of serum PSA levels in the two prostatic lesions, BPH and carcinoma prostate were highly significant.The p53 IHC staining was negative in all the 58 cases of BPH and was positive in all the 12 cases of carcinoma prostate.It can be concluded that the IHC expression of p53 is significantly up-regulated in malignant lesions along with serum PSA.More research and developments is to be done in this area of tumor suppressor genes and cancer cell biology.