Overexpression of P53Protein in Human Cervical Carcinoma

In normal cells, p53 protei n is virtually unndetectable by immunohistochemical mathcds. Mutation of p53 gene results in overexpression of the protein and thus levels of p53 detectable by immunohistochemical methods. We studied the expression of p53 protein in humanCervical carcinoma (39 cases )paraffin embedded tissue sections by immunohistochemical methods.Of these cervical carcinorna specimens overexpression of P53 protein was showed in 19 cases (48.7 % )and was a higher percentage in low differentiation rodent cancer (75 % ) than in high differentiation rodent cancer (42. 9 % ). These results suggested that overexpression of p53 often occuredin cervical carcinoma and that the percentage of overexpression of p53 Was tight relative to thedifferentiation degree of human cervical carcinoma.