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2017•Unpublished venueOpen access

Melittin: A Key Composition of Honey Bee Venom with Diverse Pharmaceutical Function

Sheng Huang, Jianhua Wang, Xiaozhong Wang, Chenghong Li

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Abstract

Melittin is the main toxic component in the the honey bee venom.It is a cationic, lytic peptide constituted by 26 amino acid residues.This peptide is an amphoteric molecule which the carboxy-terminal region is hydrophilic and the amino-terminal region is hydrophobic due to the presence of a series of positively charged amino acids.Melittin shows the interaction with biological membrane or enzyme to amphiphilic property.Based on these properties, melittin is an important candidate use for antibiotic-resistant bacteria, cancer and tumor and pathogenicity virus treatment.This review introduces the possible active mechanism of melittin and recent research progress in medical.

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Melittin is the main toxic component in the the honey bee venom.It is a cationic, lytic peptide constituted by 26 amino acid residues.This peptide is an amphoteric molecule which the carboxy-terminal region is hydrophilic and the amino-terminal region is hydrophobic due to the presence of a series of positively charged amino acids.Melittin shows the interaction with biological membrane or enzyme to amphiphilic property.Based on these properties, melittin is an important candidate use for antibiotic-resistant bacteria, cancer and tumor and pathogenicity virus treatment.This review introduces the possible active mechanism of melittin and recent research progress in medical.

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Available abstract

Melittin is the main toxic component in the the honey bee venom.It is a cationic, lytic peptide constituted by 26 amino acid residues.This peptide is an amphoteric molecule which the carboxy-terminal region is hydrophilic and the amino-terminal region is hydrophobic due to the presence of a series of positively charged amino acids.Melittin shows the interaction with biological membrane or enzyme to amphiphilic property.Based on these properties, melittin is an important candidate use for antibiotic-resistant bacteria, cancer and tumor and pathogenicity virus treatment.This review introduces the possible active mechanism of melittin and recent research progress in medical.

Key concepts: Melittin, Bee venom, Key (lock), Venom, Composition (language), Function (biology), Computer science, Chemistry

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