MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN

Background: Infertility is a global problem and as a last resort in the investigative protocol endometrial biopsy is performed to find a clue to the cause behind it. The objective of the study was to evaluate the morphological spectrum of endometrial biopsies in infertile women. Material & Methods: This cross-sectional study was conducted in Department of Pathology, Peshawar Medical College Peshawar from 21-04-2013 to 10-08-2013. Out of 168 infertile patients 8 were excluded due to insufficient representative material. The sample size was 160 infertile women of reproductive age group selected through consecutive sampling technique. In eight cases endometrial biopsy could not be assessed so these cases were excluded. Demographic variable was; age in years. Type of infertility, duration of infertility, morpholigical dating & presence of endometial carcinoma were the research variables. Descriptive statistics were calculated from data using SPSS version 18. Results: Out of 160, 102(63.75%) were primary & 58(36.25) were secondary infertile women. Mean age of the sample was 26.70+4.90 in primary & 30.55+4.79 in secondary infertile women. Mean duration of infertility was 7.06+0.5 in primary & 7.27+0.5 in secondary infertile women. Morphological changes in endometrium of infertile women included; secretory phase in 102(63.75%), disordered proliferative endometrium in 28(17.5%), irregular maturation endometrium in 11(6.8), proliferative endometrium in 8(5%) complex hyperplasia in 6(3.7%), simple hyperplasia in 3(1.8%) & discordance between glands & stroma in 2(1.2%) cases. No malignant lesion was seen in our study population. Conclusion: On premenstrual endometrial biopsy, secretory phase was the most common finding. No malignancy was reported.