2017•Cancer InvestigationRequires access

Early Prognostic Value of Monitoring Serum Free Light Chain in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation

Zübeyde Nur Özkurt, Gülsan Türköz Sucak, Şahika Zeynep Akı, Münci Yağcı, Rauf Haznedar

Abstract

We hypothesized the levels of free light chains obtained before and after autologous stem cell transplantation can be useful in predicting transplantation outcome. We analyzed 70 multiple myeloma patients. Abnormal free light chain ratios before stem cell transplantation were found to be associated early progression, although without any impact on overall survival. At day +30, the normalization of levels of involved free light chain related with early progression. According to these results almost one-third reduction of free light chain levels can predict favorable prognosis after autologous stem cell transplantation.

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Key concepts: Multiple myeloma, Immunoglobulin light chain, Transplantation, Autologous stem-cell transplantation, Stem cell, Medicine, Oncology, Internal medicine