Expression of PTEN and p53 proteins and its clinical significance in non-small cell lung carcinoma

Objective To investigate the expression of PTEN and p53 proteins and its clinical significance in non-small cell lung carcinoma(NSCLC).Methods The expression of PTEN and mutated p53 was determined using immunohistochemistry S-P method in 61 cases of NSCLC.Results Expression of PTEN was detected in 30 of 61(49.2%) NSCLC and 14 of 15(93.3%) controls(P0.05);and expression of p53 in NSCLC was higher than that in control group.PTEN expression was associated with histological type,tumor stage and lymph node metastasis;p53 expression was associated with lymph node metastasis and gender of patients.The expression of PTEN was negatively corrected with that of p53(rs=-0.282,P0.05).Kaplan-Meier survival analysis demonstrated the average survival duration was 36.5 months in PTEN negative group,and 71.0 months in PTEN positive group;The average survival duration was 70.1 months in p53 negative group,and 46.0 months in p53 positive group(P0.05).Conclusion Expression status of PTEN and mutated p53 may be used as an indicator for prognosis of NSCLC.